1. Health grounds. Where it is tested and confirmed that two lovers with blood groups AS are into a serious relationship, it is always advisable and sound counsel to break it off because of the possibility of birthing sickle cell SS prone children later on in life and marriage.
The challenge of crisis and attacks at unexpected hours, being in and out of hospitals and intensive care units more frequently, and also the possibility of losing your children at a tender age can prove too burdensome and exasperating especially when much has gone out of you by way of managing crisis, spending money and expending a lot of effort that ultimately results in pain and agony.
2. Parental disapproval. Some of you might not be as fortunate as your mates. Peers or friends to have the blessings of your Parents/Guardians in regards to your relationship.
What will be your gain or cause for rejoicing when you are cut off from your family on the account of your choice of a life partner, and what achievement is there when you as a lover or spouse do not enjoy the friendship, fellowship and support of your in-laws?
The good or ideal thing to do is to end your relationship and prospect elsewhere.
3. Loss of Interest. When your relationship becomes disinteresting or you lack the resolve to continue any step further, it is time to end it for real and for good.
When you give your relationship your best shot, do all that is within your power, scope and capacity and do not see commensurable results, burn out results and you can look forward to becoming exasperated with all the telltale signs of nagging, complaining, becoming hateful, etc.
It is time to end it and move on with your life and dignity while you still have one into another love relationship or affair.
The few reasons or excuses as presented above appear justifiable enough to end a relationship today. It is all about making each other happy and becoming fulfilled in life as a person.